Defending yourself away from home and defending your castle are two different tasks, and for many people, that suggests different tools. But if you use different guns for home and personal defense out in the world, there are some factors to consider to find the best guns for the job.
Regardless of your choices, the most important factor is familiarity and training with a particular firearm.
The provisions for better ammunition capacity, more precision, maneuverability, and ammunition choice won’t matter much if you can’t operate your home-defense gun(s) under stress.